Transformation Line

Rebuild the Appearance of Aging and Sun Damaged Skin

Jan Marini Skin Research Transformation Line combines state of the art breakthrough technologies to introduce a new era in skin rejuvenation and hydration. Transformation focuses on TGF Beta-1 (Transformation Growth Factor), Thymosin Beta-4, Pentapeptides, and VGF (Vascular Epithelial Growth Factor) to bring anti-aging technology into the next generation of breakthroughs.

TGF Beta-1 is a form of cytokine technology that is believed to act as a cellular mediator by signaling certain cellular activities that are necessary for maintaining the appearance of youthful, healthy skin. In media interviews, one distinguished medical researcher has referred to TGF Beta-1 as being essential for the normal production of collagen and elastin. The researcher also believes that TGF Beta-1 may be the answer to keeping skin young indefinitely.

TGF Beta-1

Researchers became intrigued with transforming growth factors when it was discovered that lifesaving surgery performed in-utero on fetuses during the first five months after conception left absolutely no scars. Apparently, after five months' gestation the body seals wounds more rapidly but in a haphazard manner, producing a visible and often extremely unsightly mark. Injecting non-fetal wounds with solutions containing the correct balance of growth factors has been shown to produce scar-free results. Unfortunately, at this time, the quantity and cost of these growth factors makes its use in this manner almost impossible. However, further research demonstrated tremendous value for TGF Beta-1 in its ability to signal certain actions causing enhanced skin functioning when applied topically.

Even more exciting studies at Vanderbilt University School of Medicine, Cornell Medical College, and Jefferson Medical College have shown that TGF Beta-1 stimulates significant collagen and elastin production as well as giving supplemental support to healing factors enabling wounds to heal markedly faster. Anti-inflammatory factors also appear to be beneficially affected.

Collective scientific opinion views TGF Beta-1 as a major tool in helping to reverse the visible signs of aging.

Thymosin Beta-4 is a string of 43 amino acid peptides that assist in regulating immune cells and is also a powerful anti-inflammatory and wound healing agent. The cosmetic use of Thymosin Beta-4 in an anti-aging topical treatment is a patented technology exclusive to Jan Marini Skin Research.

Thymosin Beta-4

Ongoing research demonstrates the powerful effect that Thymosin Beta-4 has on aging skin, in part because of its ability to communicate with cells and direct important aspects of critical functions, significantly reduce free radical activity and by stimulating the production of collagen and elastin.

Pentapeptides are tiny strings of amino acids (proteins) that can communicate with cells in specific ways by directly improving or correcting instructions that the cell needs in order to function properly.

Pentapeptides Unlike the older far less specific peptides, Pentapeptides GM and GD are radically different in that we can now selectively define the scope of each individual peptide. This enables us to virtually 'program' the desired type of repair or assistance.

Vascular Growth Factor is a polypeptide that assists in stimulating new blood vessel formation by helping to regulate angiogenesis.

Vascular Growth Factor

Blood vessel formation is critical in repairing wounds or damaged skin and it is believed that VEGF is very helpful in increasing blood vessel permeability, thereby enhancing the penetration of other topicals. Learn More about Transformation Anti-Aging Technology.

Read the Transformation Line Fact Sheet

 For details on each product in this line, click on the product image bellow

Transformation Cream

Containing TGF Beta-1, Thymosin Beta-4, Pentapeptides GM and GD, and VEGF

Suitable for Any Skin Type

Jan Marini Skin Research presents a powerful anti-aging technology that combines two newly developed Pentapeptides with Thymosin beta-4, Transformation Growth Factor beta-1, and Vascular Growth Factor. Transformation Cream utilizes ingredients specifically tailored to signal certain activities, including the rebuilding and repair of damaged cells, in order to maintain and augment the appearance of youthful, healthy skin. The Transformation Cream formula features a superb moisturizing base containing advanced supplemental agents such as Hyaluronic Acid and Nayad™, along with selected protective emollients. The lightly emollient cream is suitable for any skin type and absorbs immediately, leaving a silky and refined texture. Users will experience a more refined, smoother-looking skin texture and a significant decrease in the appearance of fine lines and wrinkles.

1 oz. jar
8 oz. jar Clinical/Professional use only

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Transformation Serum

Contains TGF Beta-1, Thymosin Beta-4, Pentapeptides GM and GD, and VEGF

Ideal for Oilier Skin

Jan Marini Skin Research presents a state-of-the-art formulation that combines two newly developed Pentapeptides with Thymosin beta-4, Transformation Growth Factor beta-1, and Vascular Growth Factor for the latest in breakthrough anti-aging technology. Transformation Serum utilizes ingredients specifically tailored to signal certain activities, including the rebuilding and repair of damaged cells, to maintain and augment the appearance of youthful, healthy skin.

The Transformation Serum formula is an oil-free fluid that absorbs immediately, leaving a noticeably smoother and more refined texture. The light formula is ideal for oilier skin types. Users will experience immediate visible benefits as well as long-term, significant decrease in the appearance of fine lines and wrinkles.

1 oz. dropper
8 oz. bottle Clinical/Professional use only

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Transformation Eye Cream

Containing TGF Beta-1, Thymosin Beta-4, Pentapeptides GM and GD, and VEGF

Addresses the Thinner, More Age-Prone Eye Area

Transformation Eye Cream Containing TGF Beta-1, Thymosin Beta-4, Pentapeptides GM

Jan Marini Skin Research presents a state-of-the-art formulation that combines two newly developed Pentapeptides with Thymosin Beta-4, Transformation Growth Factor Beta-1, and Vascular Growth Factor for the latest in breakthrough anti-aging technology. Transformation Eye Cream utilizes ingredients specifically tailored to signal certain activities, including the rebuilding and repair of damaged cells, to maintain and augment the appearance of youthful, healthy skin.

Transformation Eye Cream targets the thinner, more age-prone eye area to dramatically lessen the visible signs of aging. This is a highly emollient formula that provides unique lubrication and hydrating factors that bond to the area surrounding the eyes. This bonding action enables the thinner eye area skin to resist creasing and to visibly improve eyelid skin texture.

1/2 oz. jar

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Transformation Fact Sheet - Transformation Anti-Aging Technology

Breakthrough Technologies for More Normal, Healthy and Youthful-looking Skin

Transformation's breakthrough technologies truly are an amazing new area of skin care research that focuses on the instructions that are transmitted to cells and the cell's ability to interpret and carry out the instructions, resulting in more normal, healthy and youthful looking skin.

Much, if not most, of visible skin aging is skin that has been damaged or 'injured' by the sun's ultraviolet radiation that then elicits inflammatory reactions. If this damage were repaired, much like we repair a wound, then the skin would look more like it did in a younger, healthier state before the damaged occurred.

Here is a simplistic overview. Your genes are made up of DNA. Some genes are known as 'expressive genes.' The DNA in these genes contain all of the instructions - the only instructions - that cells use to build and repair tissue. DNA sends out these instructions via a messenger known as RNA. RNA messengers the instructions to the cell. In order for the cells to accurately repair damage and function properly at least two processes must occur.

1. The DNA must send out 'good' instructions. As DNA becomes damaged due to sun exposure, for example, the instructions can become increasingly incorrect causing the cells to repair in a faulty matter. The result is what we perceive as skin aging in the form of lines, wrinkles, coarse texture, etc.

2. When RNA delivers the instructions the cell needs to have the appropriate 'parts' and they need to be in good working order. For example, let's suppose you were assigned to build a car. The instructions are delivered but as you begin the process you find that you are missing parts or some of the parts you have are compromised in some way. Imagine how poorly the car would run or how it would look.

If either one of these factors is deficient in some manner, the cell will not repair or function optimally. As time goes on, the process degenerates further and we begin to perceive these inadequacies as the visible signs of aging.

The topical agents in Transformation address both of these issues. Thymosin Beta-4 appears to assist in making certain that the instructions are received and may help in correcting 'bad' information or signaling the cell to ignore the 'bad' information. TGF Beta-1 and Thymosin Beta-4 also stimulate the cell's ability to repair damage more effectively.

Pentapeptide GM and Pentapeptide GD are designed to enhance the repair or 'rebuilding' function by attaching to the cell and very precisely targeting communications or signaling so that the cell can correctly interpret and execute this data like a healthier, younger cell. Depending on which Pentapeptide we incorporate we can selectively, for example, mimic collagen synthesis or rebuild many compromised aspects that affect the visible signs of aging skin.

These concepts enable us to exert greater and more precise control over how the cell functions by introducing these powerful signaling agents. By augmenting our own repair functions we can literally rebuild the appearance of aging and sun damaged skin.

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