C-esta® Line
Unparalleled Skin Care Management
Medical research has established that vitamin C plays an essential role in every aspect of the skin's functioning, including protection from UV damage and repair of
cumulative sun-induced aging factors. It has also been proven that for vitamin C to be present in the skin in medically efficacious levels, it must be transported into cells through topical application.
The Power Behind C-ESTA: Ascorbyl Palmitate and DAE Complex
C-ESTA is a complex technology that involves stabilization, optimum skin absorption, adequate activity levels, and documented studies on human tissue that substantiate actual physiological changes. The C-ESTA Fact Sheet presents an overview about C-ESTA methods of action, its effectiveness as compared to other forms of vitamin C, and its specific benefits. The Fact Sheet focuses on C-ESTA's two distinct modes of action: Ascorbyl Palmitate and DAE Complex. Read the C-ESTA Fact Sheet.
For details on each product in this line, click on the product image bellow






C-ESTA® Cream
Containing DAE Complex

Prepare Your Skin for Dramatic Rejuvenation
The Jan Marini Skin Research C-ESTA product group containing DAE Complex is the culmination of years of clinical research resulting in the first stabilized form of topically absorbed vitamin C.
Within a short period of time the skin's texture will begin to appear smoother and more supple. With continued use, the skin will become measurably firmer, more resilient, and facial contours will appear tighter and more defined. Deeper lines will appear far less pronounced, skin pigments will look more even-toned and the skin will appear noticeable younger and healthier.
C-ESTA Cream containing DAE Complex is the evening product designed to complement the AM application of C-ESTA Serum. This lightly emollient preparation is formulated with advanced hydrating agents and beneficial extracts.
1 oz. jar
8 oz. jar Clinical/Professional use only
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C-ESTA® Eye Cream
Containing DAE Complex

Physician-pioneered Skin Rejuvenation Technology
The Jan Marini Skin Research C-ESTA product group containing DAE Complex is the culmination of years of intensive research that has resulted in the first stabilized form of topically absorbed Vitamin C.
C-ESTA Eye Cream containing DAE Complex extends these phenomenal benefits to the delicate eye area by creating conditions in the skin that encourages rejuvenation beyond any technology previously available. Within a short period of time, the eye skin texture will begin to appear smoother. With continued use, this area will appear measurably firmer, more resilient and defined. In addition, C-ESTA Eye Cream incorporates newly discovered technology that dramatically lessens the appearance of dark under eye circles. This physician-pioneered extract acts as a vasodilator and helps to clear blood and fluid which have accumulated in eye area.
C-ESTA Eye Cream containing DAE Complex completes and complements the application of C-ESTA Serum and Cream, and contains beneficial emollients that are designed to lubricate and protect the eye area.
1/2 oz. jar
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C-ESTA® Eye Repair Concentrate

Tighten and Define the Eye Area
C-ESTA Eye Repair Concentrate containing DAE Complex IV is a medically-based breakthrough for rejuvenating the thinner wrinkle prone eye area and minimizing further signs of aging. This intensive formula contains higher concentrations of lipid soluble vitamin C along with other revolutionary topical agents that dramatically reduce the appearance of fine lines and wrinkles.
C-ESTA Eye Repair Concentrate counteracts many visible aging changes by promoting a tighter, firmer more resilient eye area.
Research demonstrates that DAE Complex IV encourages collagen production, protects against and repairs free radical damage, tightens and defines the eye area and generally promotes skin that is noticeably younger and smoother.
This remarkable eye therapy creates visible improvements from the first application and with continuous use will assist in creating the optimal conditions for exceptional skin rejuvenation.
1/2 oz. measured pump top bottle
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C-ESTA® Facial Mask

Measurably Firmer and Tighter Facial Skin
C-ESTA Facial Mask is an extremely effective and versatile product that further extends the benefits of the C-ESTA technology. C-ESTA Facial Mask provides immediately visible results with each use. Facial skin will appear measurably firmer, tighter and more contoured.
Users also report noticeable improvement in the skin's texture, refinement, clarity, smoothness and hydration. Cumulative results are even more dramatic with continued use.
2 oz. tube
8 oz. tube Clinical/Professional use only
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C-ESTA® Cleansing Gel
Containing DAE Complex

Cleansing Technology Suitable for All Skin Types
C-ESTA Cleansing Gel containing DAE Complex is a newly developed cleansing technology that complements the use of C-ESTA facial products. C-ESTA Cleansing Gel produces a luxurious lather that is suitable for any skin type, from oily to dry or extremely sensitive. C-ESTA Cleansing Gel also encourages a noticeably softer, smoother more refined skin texture.
Because of the activity of our lipid soluble vitamin C along with other components of the DAE Complex, C-ESTA Gel Cleanser is a potent skin conditioner and aids in preparing the skin to be more receptive to the application of other C-ESTA products. Additionally, it is excellent for use after chemical peels, CO2 Laser resurfacing, or when cleansers containing glycolic acid may not be appropriate. Also removes eye makeup.
6 oz. tube
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C-ESTA® Lips
Containing DAE Complex II

Remarkably Effects the Appearance of Fine Wrinkling and Vertical Lip Lines
C-ESTA Lips is the first medically-based product that actually repairs the appearance of the aging and sun damaged lip area. C-ESTA Lips is a dramatically effective advancement that is targeted to specifically address aging and contour concerns associated with the lips and the immediate surrounding area. Like other Jan Marini Skin Research C-ESTA products, the formula is based on two primary modes of action: lipid soluble vitamin C and DAE Complex. C-ESTA Lips also contains two new proprietary topical agents that produce exceptional benefits for reducing the appearance of vertical lip lines (bleed lines), and also plumps and defines lip contours.
Visible results are almost immediate. The lips will appear more defined, the vermillion border more prominent, and the lips will feel smooth, firm and hydrated. However, the most remarkable and intensive benefit of C-ESTA Lips is its effect on the appearance of fine wrinkling and vertical lip lines, which significantly diminish with daily use.
1/2 oz. tube
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C-ESTA® Hand and Body Cream
Containing DAE Complex III

Addresses the Appearance of Sun Damaged and Aging Body Areas
C-ESTA Hand and Body Cream is a remarkable formulation that extends the benefits of C-ESTA facial products to other areas of the body. C-ESTA Hand and Body Cream is designed to address the appearance of sun damaged and aging body areas by encouraging dramatically softer, firmer and smoother skin. Unlike many products, C-ESTA does not merely coat the surface of the skin.
This medically-based technology targets specific aspects of sun damaged and aged skin. Furthermore, studies indicate that C-ESTA Hand and Body Cream may measurably improve or resolve the appearance of some stretch marks.
In particular, C-ESTA Hand and Body Cream provides rapid and obvious benefits to the appearance of dry sun damaged and aging hands, an area that is among the first to show age.
4 oz. tube
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C-ESTA® Perfection Treatment Foundation
Containing DAE Complex

Conceals Flaws, Redness and Other Imperfections
C-ESTA Perfection is a revolutionary treatment foundation with our DAE Complex and other advanced skin perfecting ingredients that will change the way you feel about makeup. C-ESTA Perfection is a buildable coverage makeup that ranges from a very sheer skin tone-enhancing look, to coverage that beautifully conceals flaws, redness and other imperfections.
At the same time, C-ESTA Perfection smoothes, hydrates, improves texture, minimizes fine lines and makes skin look younger and more "lifted." Available in five neutral shades.
1 oz. tube
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C-ESTA® Serum
Containing DAE Complex

For Measurably Firmer, More Resilient, Skin and Tighter, More Defined Facial Contours
Jan Marini Skin Research C-ESTA® Serum containing DAE Complex is the culmination of years of intensive medical research that has resulted in the first stabilized form of lipid soluble topically applied Vitamin C in a patented delivery vehicle, combined with other essential factors. Studies show C-ESTA is able to create conditions in the skin that enable dramatic rejuvenation. Within a short period of time the skin's texture will begin to appear smoother and more supple. With continued use, the skin will appear measurably firmer, more resilient, and facial contours will appear tighter and more defined. Deeper lines will appear far less pronounced, skin pigment will look more even-toned and the skin will appear noticeable younger and healthier.
C-ESTA Serum is a readily absorbed liquid that is compatible with glycolic acid products, Retin-ATM, other topical medications, moisturizers and make-up.
1 oz. dropper bottle
8 oz. bottle for Clinical/Professional use only
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C-ESTA® Serum Oil Control
Containing DAE Complex

Extraordinary Anti-aging Benefits with Remarkable Oil Control Properties
Jan Marini Skin Research C-ESTA® Serum Oil Control containing DAE Complex is the culmination of years of intensive medical research that has resulted in the first stabilized form of lipid soluble topically applied Vitamin C in a patented delivery vehicle, combined with other essential factors. Studies show C-ESTA is able to create conditions in the skin that enable dramatic rejuvenation beyond any technology previously available. Within a short period of time the skin's texture will begin to appear smoother and more supple. C-ESTA Serum Oil Control leaves the skin soft and radiant and significantly inhibits oil breakthrough.
With continued use, the skin will become measurably firmer, more resilient, and facial contours will appear tighter and more defined. Deeper lines will appear far less pronounced, skin tones will even and the skin will appear noticeable younger and healthier.
C-ESTA Serum is a readily absorbed liquid that is compatible with glycolic acid products, Retin-ATM, other topical medications, moisturizers and make-up.
1 oz. measured pump-top bottle
8 oz. bottle for Clinical/Professional use only
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C-estamins® With BioCell

Promotes Energy and Provides Support for Enhanced Well-Being and Longevity
C-ESTAMINS are the most advanced and comprehensive anti-aging nutritional supplement available today. C-ESTAMINS supplies many critical components that have been shown to promote energy and provide support for enhanced well-being and longevity. Our once-daily packets are also formulated to assist in noticeably improving the appearance of aging and sun-damaged skin.
Patented BioCell Technology
C-ESTAMINS contains a patented technology called BioCell Collagen II®. BioCell has been the focus of two double blind placebo controlled studies that confirm the effects of BioCell on factors that influence skin elasticity and volume, improving skin texture and reducing the appearance of fine lines and wrinkles.
BioCell is a revolutionary discovery that addresses one of the common denominators in aging: loss of connective tissue. Connective tissue helps to give form and structure by acting as a "filler agent" and providing volume.
Rejuvenating Hyaluronic Acid
One of the primary components involved in this process is Hyaluronic Acid, a water-filled gel. The human body produces approximately 3,000 milligrams of Hyaluronic Acid (HA) daily. Because we lose Hyaluronic Acid each day, our body constantly produces more in order to replenish daily loss.
As we age, sun exposure and factors such as a decline in hormones cause a sharp drop in our internal concentrations of HA. By the time we are 40 years of age, most people are producing significantly lower levels of HA.
Some of the highest levels of HA are found in the skin. Many researchers believe that if we could maintain or increase our levels of HA, we would prevent many of the outward signs of aging such as wrinkles and sagging skin.
Replenishing Hyaluronic Acid Orally
What if we could increase our internal levels of HA? Unfortunately, topical application, such as moisturizers contain extremely large molecules that can only help to lock in existing surface moisture. BioCell is a breakthrough technology where the HA molecule has been reduced and combined with other constituents of connective tissue into a natural matrix. Taken orally, BioCell is easily absorbed by the body. It is the most potent and well documented substance of this type shown to increase internal stores of HA and visibly improve the appearance of skin.
Benefits to Patients
More than half of the body's HA is found in the skin. Numerous clinical studies have demonstrated that by increasing HA through oral supplementation, users report:
- A visible lessening of facial wrinkles
- Improved facial and body skin texture
- Noticeably increased moisture content
- An increased appearance of firmness and volume
- Jan Marini Skin Research is the only company to produce a comprehensive anti-aging supplement that contains the full recommended amount of BioCell
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C-esta® Fact Sheet
Ascorbyl Palmitate
What is Ascorbyl Palmitate?
Ascorbyl Palmitate is a lipid (fat) soluble form of vitamin C. Ascorbyl Palmitate maintains all the physiologic activity of vitamin C without the problems that can be associated with ascorbic acid (the common water soluble form of vitamin C).
Ascorbyl Palmitate turns on cellular machinery. Human cell cultures designed to closely simulate the human body demonstrate this effect. By enhancing the cells' ability to function more effectively, cells are better able to repair any damage and generally "act" in a younger manner.
Ascorbyl Palmitate is a neutral pH (non-acidic) molecule. C-ESTA can be applied to any skin type without irritation as opposed to ascorbic acid, which has extremely low acidic pH and can create inflammation. C-ESTA does not sting or burn. C-ESTA can be used with glycolic acid, Retin-Aä and after laser resurfacing to assist in the recovery process.
Because Ascorbyl Palmitate is fat soluble, it penetrates the skin very rapidly and intersperses in the cell membrane. This affinity with the cell membrane results in tremendous antioxidant benefits and helps to prevent cellular aging such as:
- Cross linking of collagen
- Oxidation of proteins
- Lipid peroxidation
Ascorbyl Palmitate acts as an anti-inflammatory. The molecule was tested on several human inflammatory models. Studies demonstrated anti-inflammatory activity when Ascorbyl Palmitate is applied to psoriasis. Studies also show that Ascorbyl Palmitate can dramatically decrease UVB-induced erythema (sunburn) when applied topically.
Ascorbyl Palmitate is more active than ascorbic acid. A study conducted at the University of North Carolina compared the efficacy of ascorbic acid and Ascorbyl Palmitate in the suppression of phorbol ester-induced tumor production (tumors nearly identical to those caused by UV light exposure). This study demonstrated that, while Ascorbyl Palmitate and ascorbic acid both have tumor suppressing activity, Ascorbyl Palmitate was 30 times more effective than ascorbic acid at 1/4 the dose.
Ascorbyl Palmitate is extremely stable. Ascorbyl Palmitate is the only vitamin C molecule that maintains vitamin C activity for long periods of time. C-ESTA products have a normal two-year shelf life.
Ascorbyl Palmitate enhances vitamin E activity in the skin. Because Ascorbyl Palmitate can reside in the cell membrane, it can regenerate the vitamin E radical on a continuous basis. This is as opposed to ascorbic acid, which only interacts with vitamin E at the interface of the water-soluble and lipid components.
Ascorbyl Palmitate has been proven to be physiologically active in human cell cultures.
- Ascorbyl Palmitate shows greater activity than Ascorbic Acid in fibroblast growth and collagen production.
- Ascorbyl Palmitate shows greater activity than Ascorbic Acid at lower doses.
Ascorbyl Palmitate has better skin absorption and retention than Ascorbic Acid. In a study conducted by a division of Proctor & Gamble, skin absorption was compared between Ascorbyl Palmitate and ascorbic acid. At two hours, skin absorption of Ascorbyl Palmitate was far greater than ascorbic acid. At 24 hours, the amount of Ascorbyl Palmitate was over nine times greater.
Patients and physicians observe the following benefits:
- Thicker dermis
- Skin appears more resilient
- Skin appears plumper and thicker
- Decrease in the appearance of fine lines and wrinkles
- Skin appears softer, smoother and more refined
- Reflective quality of skin is enhanced
- Lessening of redness due to irritation and inflammation
- Facial skin appears more even toned
- Skin that tends toward sensitivity is far less reactive;
- Lessening of the appearance of telangiectasis
About DAE Complex®
DAE Complex is a powerful "antioxidant cocktail" that acts by stabilizing cell membranes. Stability of the cell membrane is critical to insuring that the cell functions at optimum levels. DAE Complex protects and enhances cellular activities. DAE Complex contains a proprietary delivery agent that acts as a penetration enhancer, enabling Ascorbyl Palmitate to penetrate to a more beneficial level. C-ESTA causes a noticeable improvement in the appearance of sagging and redundant skin. The delivery agent in DAE Complex is also a precursor of Acetyl Choline. Acetyl Choline is partly responsible for muscle tone. C-ESTA's DAE Complex stimulates Acetyl Choline resulting in the appearance of tighter and firmer skin with more defined facial contours.
Patients and physicians observed the following benefits:
- Increased muscle tone
- Lessening of the nasolabial fold
- Decreased redundancy of upper eyelids
- Overall appearance of tighter and more defined facial contours
- Overall appearance of skin IS younger and healthier
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